Biosensing in Precision Medicine R&D Center
Project Description
The "Biosensing in Precision Medicine" team at Peking University has developed an intelligent closed-loop diabetes skin patch（糖尿病智能闭环皮肤贴）. The patch, button-sized, significantly reduces the overall volume and cost of current commercial closed-loop systems, aiming to make it affordable for every diabetic patient in China. The closed-loop diabetes skin patch contains miniature diabetes sensors and a miniature insulin injection pump（胰岛素注射泵）, both controlled by electrical signals. It can precisely, simultaneously, and continuously perform blood glucose monitoring and insulin injection functions in real-time. By intelligently controlling insulin injection quantity and rate based on blood glucose concentration, it stabilizes blood glucose levels. The flexible nature of the device for skin conformity reduces wear discomfort and sensor signal noise. The patch's biodegradable material makes wearing the device safer. The closed-loop patch is compact, wearable, painless, lightweight, and cost-effective. Moreover, the system has achieved effective treatment in diabetic rats, successfully achieving stable blood glucose control in them. The intelligent closed-loop diabetes skin patch is expected to open up new avenues for basic research on closed-loop systems and practical applications in diabetes management. Compared to current commercial closed-loop systems priced between 30,000 to 90,000 RMB, with a volume of approximately 5 cm x 9 cm x 2 cm, it features small size (button-sized) and affordability (500 RMB for consumables), making it accessible to hundreds of millions of diabetic patients.
Lead Arranger
Cui Yue, Researcher and Doctoral Supervisor at the School of Materials Science and Engineering at Peking University. Before returning to China, she served as an Assistant Professor at Utah State University and an Associate Professor at University of Cincinnati in the United States. With nearly 10 years of teaching and research experience in the United States, she returned to China in 2016 as a high-level overseas talent. She has received honors such as the Eager Award from the National Science Foundation (NSF) of the United States, the Scientist Development Award from the American Heart Association. She has also served as a Project Review Expert for the NSF, including the Division of Electronic, Communications, and Cyber Systems (ECCS), Division of Civil, Mechanical and Manufacturing Innovation (CMMI), Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET), as well as a Project Review Expert for the National Institutes of Health (NIH) of the United States, the Natural Sciences and Engineering Research Council of Canada (NSERC), the Israel Science Foundation (ISF), and the National Centre for Scientific Research (CNRS) of France.
Her research interests and directions focus on Biosensing in Precision Medicine. Targeting clinical medicine, her goal is to develop new types of biosensors that can be used at home, carried, or worn for precise detection of disease biomarkers, enabling early screening, real-time monitoring, long-term management, and treatment guidance for diseases. Specific areas of research include wearable sensors, closed-loop systems, Bio-Microelectromechanical Systems (Bio-MEMS), and immunochromatographic test strips.
